HNF TRIAD Academic Partner Connecticut Children’s Publishes Results of CMT Pediatric Natural History Study to Better Understand Ankle Function and Gait
HNF-funded research sought to determine how age and CMT type affect ankle strength in children. A detailed understanding of neuropathy progression is needed to guide informed treatments to improve or prevent a decline in gait function.
Gait analysis and range of motion strength testing were used to evaluate children with both CMT1 and CMT2. The children with CMT1 had slightly more ankle strength that continued to increase with age until it plateaued at about 13 years, while the children with CMT2 were weaker and plateaued earlier but did not seem to get weaker with age. This highlights the importance of having an in-depth understanding of gait at the individual patient level using comprehensive gait analysis, including valid and reliable strength measures.
HNF continues to fund critical Pediatric Natural History Studies for CMT in preparation for clinical trials and to improve treatment outcomes.
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