Recruiting Now: FLX-787 Phase 2 CMT Muscle Cramp Study

Flex Pharma

Flex Pharma, Inc. is a biotechnology company developing innovative treatments for cramps and spasticity associated with severe neurological diseases, such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS) and peripheral neuropathies such as Charcot-Marie-Tooth (CMT). In October 2017, Flex initiated a Phase 2 study of CMT, referred to as the COMMIT study. The study will evaluate FLX-787, the Company’s co-activator of TRPA1 and TRPV1, in patients with CMT who suffer from muscle cramps. Approximately 120 subjects at 20 study centers across the United States are expected to take part. Participants will be in the study for approximately three months and will visit the study clinic three times. Enrollment is currently ongoing.COMMIT logo

“Many of our patients with CMT neuropathy suffer from frequent and severe muscle cramping which can limit their activities of daily living and have a profound impact on their quality of life,” reported CMT clinical trial lead investigator, Dr. Nicholas Johnson, Assistant Professor of Neurology, Pediatrics and Pathology at the University of Utah. “We are hopeful FLX-787 will provide significant clinical advantages because of its safety profile and the lack of systemic exposure.”

Dr. William McVicar, Flex Pharma President and CEO, added “An important goal of the Hereditary Neuropathy Foundation (HNF) is to raise awareness of inherited neuropathies, such as CMT. Flex Pharma and the HNF both support research aimed at addressing the needs of patients, so we are excited to be partnering with the HNF in this effort to find a treatment for CMT patients suffering from painful cramps that impact their quality of life.”

FOR ADDITIONAL INFORMATION ABOUT THIS CLINICAL STUDY, PLEASE VISIT CLINICALTRIALS.GOV, IDENTIFIER NCT03254199 OR HTTP://COMMITSTUDY.COM

*Designated HNF Center of Excellence

ARIZONA

Mayo Clinic (Dr. Ross)
13400 East Shea Blvd.
Scottsdale, AZ 85259

Contact:
Dr. Mark Ross
Phone: 480-301-6711
[email protected]

FLORIDA

Mayo Clinic (Dr. Kennelly)
4500 San Pablo Road
Jacksonville, FL 32224

Contact:
Arijana Draganovic
Phone: 904-953-6912
[email protected]

University of Florida (Dr. Wymer)*
1149 Newell Drive
Gainesville, FL 32611

Contact:
Rebecca Dettorre
Phone: 352-294- 8778
[email protected]

University of South Florida (Dr. Vu)
13330 USF Laurel Drive
Tampa, FL 33612

Contact:
Brittany Harvey
Phone: 813-974-9413
[email protected]

MASSACHUSETTS

Brigham and Women’s Hospital (Dr. Amato)*
60 Fenwood Road
Boston, MA 02115

Contact:
Kristen Roe
Phone: 617-525-6763
[email protected]

Massachusetts General Hospital (Dr. Seyedsadjad)
165 Cambridge Street
Boston, MA 02114

Contact:
Peter James
Phone: 617-643-4218
[email protected]

COLORADO

University of Colorado (Dr. Quan)
12631 East 17th Avenue
Aurora, CO 80045

Contact:
Brianna Blume
Phone: 303-724-6386
[email protected]

IOWA

University of Iowa (Dr. Shy)
200 Hawkins Drive
Iowa City, IA 52242

Contact:
Heena Olalde
Phone:  319-356-8326
[email protected]

MINNESOTA

University of Minnesota (Dr. Walk)*
420 Delaware Street
Minneapolis, MN 55455

Contact:
Sarah Hilbert
Phone: 612-626- 4690
[email protected]

 

MISSOURI

Saint Louis University (Dr. Kafaie)*
1438 South Grand Boulevard

St. Louis, MO 63104

Contact:
Susan Eller
Phone: 314-977- 4867
[email protected]

PENNSYLVANIA

Penn State Milton S. Hershey Medical Center (Dr. Lowden)
30 Hope Drive Hershey, PA 17033

Contact:
Ruth Stewart
Phone: 717-531-0003 ext. 287666
[email protected]

CONNECTICUT

Hospital for Special Care (Dr. Felice)
2150 Corbin Avenue
New Britain, CT 06053

Contact:
Dr. Agnes Jaremko
Phone: 860-612-6356
[email protected]

KANSAS

University of Kansas Medical Center *(Dr. Statland)
3901 Rainbow Boulevard
Kansas City, KS 66160

Contact:
Hellen Tanui
Phone:  913-945-9934
[email protected]


NEW YORK

Columbia University (Dr. Brannagan)*
710 West 168th Street
New York, NY  10032

Contact:
Phone: 212-305- 6035, Arruem or Allan
[email protected] [email protected]


WASHINGTON

St. Luke’s Rehabilitation Institute*
715 South Cowley Street, Suite 210
Spokane, WA  99202

Contact:
Ann Cooper
Phone:  509-939-8079
[email protected]